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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin <t>K1</t> (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.
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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin <t>K1</t> (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.
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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin <t>K1</t> (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.
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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin <t>K1</t> (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.
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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin <t>K1</t> (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.
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ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin K1 (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.

Journal: Endocrinology

Article Title: Abaloparatide Maintains Normal Rat Blood Calcium Level in Part Via 1,25-Dihydroxyvitamin D/osteocalcin Signaling Pathway

doi: 10.1210/endocr/bqad117

Figure Lengend Snippet: ABL has less direct effect on Ocn formation. (A) 1,25-(OH) 2 D induces Gla-Ocn formation in concentration-dependent manner. (B) Vitamin K1 (VK) enhances 1,25-(OH) 2 D-induced Gla-Ocn formation but reduces 1,25-(OH) 2 D-induced Glu-Ocn production. (C) ABL has little effect on Gla-Ocn and Glu-Ocn formation. n = 3. a P < .01, compared with Veh; b P < .05, c P < .01, compared with each concentration of VK.

Article Snippet: 1,25-(OH) 2 D (Catalog No. D1530), 25-(OH)D (Catalog No. H-083), vitamin K1 (Catalog No. V3501), and proteinase inhibitor cocktail (Catalog No. P8849) were purchased from Sigma-Aldrich (St. Louis, MO).

Techniques: Concentration Assay